340 



R««t*reh I D«v«1op«MC Ett«bli«haeat, 

 Irititli-Aaericao Tobacco Co. Ltd.. 

 SOUTKMflTOll. 



DC/CA1,/46H VJ ^ I5tk Hoveiibtr 1971. 



KiUTivt coWTMBirriOHs OF Hicornre a;<d carbon MONOxioe to 



^ tJVUAN HftSIOLOCICAL RZSPONSE 

 -ffre^rt »o. RD.8W-R) 



^ /. 

 »' ^ 



JL-MMARY AND CONCLUSIONS '</■ 



*t - - . ■ y •. 



^ trial has been conducted to iDvestigatc the feparate contribution 



■ /<, Cy 



of aicot^ie and carbon monoxide to the ihort-^e^ phydological changes 



which ate ^1i$erved in hunaa subjects as a resultOf tooklo^ a cigarette. 



Diffieislt/^^t been experienced io interpreting (ke reMl^, 



•n4 it ii not f«t po)|«iblc to draw fin conclusions cooci^a^ng th« 



effect of carbon ■otkoxi^^v A statistical treatacnt of the results 



Suggested that carboa •oroxvdjt had affected the heart rate and blood 



pressure in the opposite rfirectv^ to that expected. Bowever, for 



purposes of statistical analytla it^s not possible to take account 



of certain observations which could have^ltered the conclusions. 



For these reasons it will be necessary to catry out further invcstigatiei 



before the effects due to carbon aonoxite can br' stated with confidence, 

 and coopered with those due to nicotine. "" ,.^ 



