355 



Croup tcjcarch I D«v«lo{>**flC Ccactc, 

 KritUb-AacricM Tobacco Co. Ui., 

 SOUTHAMnOa. 



V 

 AKC/RTT/Ki/Uj 12ch D«ceA«r. 1974 



Q 



Oy 



^r DrtWACTiow or s^OKE ahd the smokik 



PAJy 3: rait EfTtCT OF CIC.^AETTE STjOKI'mC 

 08/^ IV^ COBTDiCENT >:iCATrVE VAJtlATIOW 



\(^port So. IU>.1164-R) 





/< . 



^ X^ effects of cigarette siDokiQ( oil J^ectrical activity in the 



o ' ^ 



Vrain, W^sured bjr clectroeocephalography <^CK), ar« Wing investigated 



«s part of i^^study of the interaceioaa between a^ SBok«r and the cigircttt. 



Of^tn^ex Q^ brain activity ^ich has b«cn we»9vlti ^RLf%* cootiagenc 



negative variation ^^TV) , or expectancy wave. The OTV [a a sl«v potcatial 



•hift in the baseline t$iO which occurs in the interval bcCvctn two 



■K .* Cu - 



•tiauli (*uch aa ool^iLor i>^c (lashes), if the sacoad one re^uirasX 



a decision or action by tba sub5V^- 



The aagnitude of the CKVwas d^^rained a nuober of tines before 

 and after each subject saokcd a dgaretO^ Soae saokers showed an iacrcase 

 and others a decrease after they had vaokc^^'^ 



This divergence of response can be Interpreted in two different ^ 



ways. Nicotine (which has been assuaed to b« the aAln pharmacologically •• 



f hi 



active component in ssioVe) say act in a bi-phasic Manner «<r«L the r at a 9 



stinulant (CNV increase) or a depressant (CNV decrcosa). l(o^ver, nicotine 



could act only »i a stinulant and the direction of cJtanga la CfV aasoicude 



would depend entirely on the level of activity in the brain before sacking. 



