373 



Croup t«ac«reh 4 0«v«lopa«sC Ctatra, 

 lritl«b-AMrlC4a Tob4ce«. Co. U4., 

 SOUTHAKPTOfl. 



CA>yia<A/UC/ltA/4«D-2 )ttt lurch. 1981 



0-, ilCOTIMt STUDIES; A StCOKD R£POKT . 



^ISTTMATION OF WHOLE BODY NICOTINE DOSg BT 

 ' ^WAKt KICOTIKE AND COTININE MEASUREMENTS 



'^^pLeport Ro. IU).1792 Rcicrlcctd) 

 ' JLU)-L023-8l C.5 



•'^. SUMMARY ■ .';;.. 



'"y ^ Cvldcoc* !• prcseatcd which ln<flemte« th«C urinary aival/tlt of 



olcp^tac *oA cotlalDc can b« used to predict ch« whole body alcotlne dose 



to Che -<«t follovloi iQCrtvcQous adalnlscrttto^. Ihese data ere coapared 



with ether published fladln«s oo alcotlae (ollowlQ;. iDtrtveaoua dosloi la 



rats aii4 doslol^hj lohalatloo la hoth rats and maa. O^ 



It cao be coQ&u^ed fro* the cooperative studies that enalysls of 



nicotine end eotlBlne lit' urine Is likely to be e |ood Indicator of whole 



body alcotlne dose U aea. ^ /e, 



Thls technique has an iMM^late end direct relevance for 



(1) enlael toxicity stadias It^/^he cooperative asscssaent of 



cigarettes, •.'■ _ 



(11) huaaa behavioural studies la the Ueessaent of ea Individuals* 



• 



alcotlne dose la response to ■odKlcatlep la cigarette deslga. 



■ / 2 



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W 



o 



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