390 



-2- 



I . Introduc tlon , . 



1 . 1 "Janu»" Objectives and Team 



The General Report contain* all the inforvation that la generally 

 applicable to all 'Janus B" long-term experi oients. Special 

 details, which concern only specific "Janus 8" experlBcnts will 

 be described in subsequent reports. 



In 1969, Battcllc-Instltut a.V., Frankfurt/Main, was requested 

 to carry out lon(-terei skin palntlns expcriaents with solutions 

 of tobacco-snoke condensate on nice. A duration of five year* 

 was originally envisaged for the experlaents. 



Frosi literature It Is known that long-tera skin painting experi- 

 ■ents have been carried out for some decades. Ever since It wa* 

 possible to produce neoplasas on test aniaal* by the applica- 

 tion of tobacco product* thla aethod was used la experisiental 

 pathology to Investigate alao the carcinogenic effect of tobacco 

 products. 



The project was aimed at first at testing and evaluating the 

 ■carclnogeale action of cigarette saoke en aouse skla". The 

 •xperlaeats were to be based on experlaeat* carried out by the 

 Tobacco Research Council, Barrogata. England. la the course of 

 year*, bowever, certain change* were aade, and the "Harrogate 

 procedure" was aodlfled. 



To carry out the extenalra experlaental prograiaa, It «a* 

 nece**ary to *et up an Independent working group and to erect 

 a apeclal building. 



In 196$, the year of preparation, planning and trial runa for 



the long-tera experiments, the team Included four parsons: two 



scientist* (one chemist and one biologist) and temporarily two 



cheaical technicians. — 



(B 

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BATTen.e-INSTITUTe.V. .^RAUKFURTAMMAIN M 



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