404 



■ 10- 



OUTLINF 1071-72 



GENERAL 



Although mouse-skin painting is likely to remain an Import ant 

 recognised test of carcinogenesis for somo considerable time to 



come, the emphasis is changing and more importance is being placed 



on assessing materials using a variety of techniques. This is 



particularly true when considering new materials. For tobacco 



smoke the empliasis on inhalation tests has still not resulted in 



the development of a routine chronic technique, still less on an 



acceptable method of test. 



It is hoped that our own laboratory facilities will be set up 



during the coming year. Vhen those become available, the programme 



will initially be' concentrated on developing inhalation techniques 



« 

 with special attention to the accurate measurement of the dose 



retained in the respiratory tract. Measurement and control-of the 



dose retained from different clgarettos is an essential prerequisite 



for comparing results from inhalation experiments. 



Vith this background, it is anticipated that mouse-s^in painting 



experiments will be continued at Battelle and although the demands 



are reducing the next long-term test has already been planned. 



Future requirements are somewhat less certain but it is likely that 



such tests will be required for the examination of new technical 



developments in the recons 1 1 tu t ion process and tlie incorporation 



of different materials or additives in the process. 



Fvirtlier efforts will be concentrated on the developmont of 



reliable short- or medium- term tosts ii>iii(* holli rk in-p.< in V. in,-; .nti'l 



inli.i la tion lochniquos. It is aniicipa toil that tlie proinotioij test 



BW-W2-00228 



