414 



Howtytr, these cofxjgnsa'.es are artificially produced under laboratory 

 copditions and, a» ao^. have little, if any, relation to cigarette smoke as it 

 reaches the smoker. ^ Bfelf er, the results obtained on the skin of mice should 

 not be extrapolated \<0^i ^^P% tissue of the mouse, or to any other animal 

 species. Certainly such'^^n re^uUs should not be extrapolated to the human 

 lung. ^- ^ 



For many years various 4vbstanc*s in cigarette smoke or in ciga- 



'' - ' '/ ^ 



rette smoke condensates have been reporUed by some to be responsible for 



disease in smokers. One example is ben2o(aJj3yrene, which is a carcinogen; 



that is, a sobstance which has caused cancer in Animals under experimental 



conditiona. Tn<i Surgeon General 's 1964 report said',C^lpeDto(a)pyrene is 



one of the two most'Aptent of the seven carcinogens detec?t^d in tobacco smoke 



and it is presenf In mucrtl^rger quantity than any of the other Otrcinogens 



listed. " Dr. Ernest L> Wyndfir, well known for his mouse-painting experi- 



ments. has repeatedly linked benzq<a)pyrene to the skin tumors that he was 



able to produce in his mice. >-. ^^ 



However, io 1966, the siniificaKe of benzo(a)pyrene in animal 



tumor production was seriously questione^l. Irr October 1969. Dr. E. Cuyler 



*^ 



Hammond, a Vice President of the American Cance^^ociety, announced that 

 after an extensive survey involving roof workers who nec9$.sarily must inhale 



large amounts of benzo(a)pyrene in their work, he had concl.j<^d that the 



t 



substance may have to be ruled out as a cause of lung cancer. C < 



Another area of experirr.entation is s moke inh alation. Ani mal '^ 



— —r o 



smoke inhalation experirr.ents have been conducted for well over 30 years. 3 



