Physiology of Pathogenic Microbes. 63 



chemical action to which the nutrition of these 

 germs gives rise; the emphysematous tumors of 

 symptomatic charbon and of traumatic gangrene are 

 caused by the abnormal production of gas which 

 accompanies the fermentations provoked by the 

 anaerobic microbes of these diseases. 



2. Pathogeny of remote and general manifestations. — 

 Anatomical alterations remote from the original point 

 of infection may be produced as a consequence of the 

 penetration of the pathogenic microbes into the lym- 

 phatics and blood-vessels; their pathogeny is identi- 

 cal with that of the local manifestations. 



The arrest of the microbes in vessels of small cali- 

 ber may become the starting point of secondary me- 

 chanical lesions; we refer to microbic embolisms, 

 comparatively frequent in general infectious diseases, 

 and which are followed by infarcts, stases, etc. But 

 it may happen that the secretion-products alone pene- 

 trate into the circulation, the bacteria remaining in- 

 trenched at the primary focus ; we may also have 

 localized alterations dependent upon special proper- 

 ties, dissolving, phlogogenic, or pyogenic, of these 

 products. 



Besides the functional troubles resulting directly 

 from the anatomical lesions, primary or secondary, 

 seated in the various organs, we have to consider 

 the genesis of the general manifestations which ac- 

 company microbic diseases, either local or general. 



Fever is one of the most frequent symptoms ; a 

 certain number of soluble microbic substances excite 

 hyperthermia. This almost always results from a gen- 

 eral nutritive excitation of the tissue elements, from 

 contact with these substances ; but it may also be the 



