232 Manual of Veterinary 3Iierohiology. 



the veins or in the peritoneum, five only developed 

 tubercular lesions. 



The goat forms a specially unfavorable field for the 

 development of tuberculosis and was long considered 

 to be absolutely refractory to the inoculated as well as 

 to the spontaneous disease. M. Nocard has recently 

 described the evolution of the disease in a goat inocu- 

 lated in the jugular five years before, and which at 

 last had become afiected w4th mange ; M. Colin has 

 also produced the disease in a goat inoculated under 

 the skin with particles from the ox. 



The laboratory animals — guinea pigs and rabbits — 

 are very susceptible to the disease. The guinea pig 

 is endowed with a quite special receptivity which 

 makes it the reagent par excellence for tuberculosis. 



Subcutaneous inoculation on the internal face of 

 the thigh in the guinea pig is followed by a local ab- 

 scess when the inoculated substance contains at the 

 same time pyogenic germs, or only by a few yellowish 

 granulations if it is pure ; at the end of ten to fifteen 

 days there supervenes an engorgement, sometimes an 

 abscess, of the superficial inguinal lymphatic glands; 

 the sublumbar glands of the corresponding side are 

 invaded about the twentieth day ; between the twenty- 

 second and twenty-fifth days tubercles appear in the 

 spleen and retro-hepatic glands ; the lungs, liver, and 

 the other lymphatic glands are attacked later. The 

 disease lasts about two months. When the inocula- 

 tion has been made at the ear the invasion takes place 

 by the anterior lymphatics, and the lungs are attacked 

 before the abdominal viscera. 



Subcutaneous inoculation on the internal face of 

 the thigh or at the ear, in the rabbit, does not give 



