Microbic Diseases Individually Considered. 253 



guinea pig were cultivated and successfully inocu- 

 lated to the guinea pig and the rabbit. 



Bacillar tuberculosis of Courmont. — M. Courmont 

 found in tubercular lesions of the pleura in an ox — 

 lesions which did not contain Koch's bacillus — a short 

 bacillus with its substance condensed at the two ex- 

 tremities and with a clear slightly constricted median 

 zone; this bacillus is never associated in chains or 

 in diplo-bacilli; it is aerobic and anaerobic. It is 

 easily cultivated and grows rapidly in all the culture 

 media and at wide limits of temperature, even up 

 to 46°. 



Guinea pigs succumb in four to eight days with a 

 local oedema and great enlargement of the spleen, but 

 without tubercular lesions. The bacilli are abundant 

 in the serosity of the oedema and in the blood; after 

 several passages through the guinea pig a caseous 

 abscess develops at the place of inoculation. 



Rabbits contract a more or less complete tuber- 

 culosis; an abscess forms at the place of inoculation, 

 and, after death, disseminated or confluent tubercles 

 are found in the spleen, liver, and lungs. These 

 tubercles have the classic structure ; they do not con- 

 tain Koch's. bacillus but those described above. 



A culture twenty days old having been inoculated 

 to guinea pigs the latter died in less than ten days 

 with a generalized tuberculosis in which the lesions 

 contained Courmont's bacillus. The property of be- 

 getting tubercles in the guinea pig appears to exist 

 in cultures only from the twentieth to the twenty- 

 fifth day; at other times the inoculated guinea pig 

 dies without tubercles. The tubercles of the guinea 

 pig kill the rabbit, but without tubercular lesions. 



