31ierobic Diseases Indwidaally Considered. 259 



the subcutaneous cellular tissue is sometimes followed 

 by a violent access of fever in the course of the third 

 day ; then the local lesions appear in the form of an 

 extensive engorgement wliich bursts and ulcerates, 

 the chancre thus produced having a great tendency 

 to spread. Farcy buds and cords, and rodent ulcers 

 often appear on other parts of the body; sometimes 

 an intense and painful lameness — expression of glan- 

 derous arthritis — supervenes without apparent cause, 

 the stifle being the most frequent seat of the specific 

 inflammations. Out of twelve dogs inoculated by 

 Prof. Reul, four died, three were killed, and five 

 spontaneously recovered. Inoculation of glanders to 

 the dog often gives, as sole reaction, a superficial 

 ulceration wdiich cicatrizes in eight to fifteen days. 



In the guinea pig inoculation by scarifications 

 (these are made on the neck or back) is followed by 

 ulceration of the w^)unds on the fifth to the tenth 

 da}^; these ulcers may, later, cicatrize. Subcuta- 

 neous inoculation gives voluminous abscesses in the 

 whole chain of lymphatic glands proximal to the 

 place of inoculation. In both cases the animal be- 

 comes emaciated and dies more or less rapidly with 

 tubercular foci in the spleen, liver, lung and lymphatic 

 glands. The local lesion — the ulcer — suffices to es- 

 tablish the glanderous nature of the inoculated prod- 

 ucts. When the inoculation is made in the perito- 

 neum a pronounced swelling of the scrotum is ob- 

 served from the second to the third day, this swelling 

 indicating the specific inflammation of the testicular 

 membranes. This peculiarity can be utilized for the 

 purpose of making a rapid diagnosis of the disease 

 (Straus). 



