Microbic Diseases Individaally Considered. 263 



to which it has been carried in various ways and es- 

 pecially by the harness, grooming utensils, litter, etc.; 

 it gains entrance through accidental abrasions of the 

 integument. According to Babes, however, the 

 glanders virus can make its way into the organism 

 through the intact skin, penetrating the oriUces of 

 the hair follicles. This penetration will by facilitated 

 by frictions. M. Nocard undertook to test this asser- 

 tion by rubbing an ointment charged with glanders 

 bacilli on the skin of three asses and fifteen guinea 

 pigs. Of these, only two guinea pigs became glaud- 

 ered, a result which considerably reduces the risk 

 which might be inferred from the above conclusions. 



Certain circumstances are of such a nature as to 

 favor the implantatio-n of the bacilli of glanders. 

 We recognize the predisposing influence of bad hy- 

 gienic conditions, excessive fatigue, and chronic ex- 

 hausting diseases. Chronic forms of glanders may 

 assume acute characters under the same influences. 



The bacilli of glanders having once obtained en- 

 trance into the economy multiply generally at the place 

 of their penetration, thus producing local lesions. 

 They quickly invade the lypmphatic system (which 

 becomes the seat of specific inflammations, glander- 

 ous lymphangitis and adenitis) and the blood ; by the 

 latter they are carried throughout the system but 

 they only develop in the tissues predisposed to their 

 attack: respiratory mucous membrane, integument, 

 testicles, and synovial membrane of articulations and 

 tendons, etc. 



The specific lesions present certain analogies with 

 those of tuberculosis. The primary lesion — the glan- 

 ders tubercle^is purulent at its center and destitute 



