284 Manual of Veterinary Microbiology. 



abdominal viscera are altered only in their serous 

 covering, the tissue proper being unafiected, whilst 

 the thoracic organs are exempt from lesions. 



The injection of virulent material into the veins is 

 followed by a generalized pseudo-tuberculosis, the 

 bacilli being found in tufts in the center of all of the 

 lesions. 



In both cases death occurs from the ninth to the 

 twentieth day. Subcutaneous inoculation in the 

 guinea pig always produces a voluminous local ab- 

 scess ; the corresponding lymphatic glands also sup- 

 purate and recovery takes place only after a period 

 of great emaciation, leaving behind it an induration 

 of the lymphatics. Generalization may, however, be 

 occasionally observed. 



Intra-vascular inoculation in the sheep and in cat- 

 tle also produces nodular lesions distributed througli- 

 out the viscera, but death does not immediately fol- 

 low, the disease developing very slowly. 



Hypodermic inoculation in the same animals pro- 

 duces an abscess which ulcerates on difl'erent occa- 

 sions, seems to heal, then reappears later, exactly as 

 in the natural disease. 



Subcutaneous inoculation in refractory animals oc- 

 casions an abscess which quickly heals. 



Tetanus. 



Tetanus occurs spontaneously in all the domesti- 

 cated animals and in man ; it is more frequent in the 

 horse, ox, sheej), and goat, but it has also been ob- 

 served in the pig and dog. 



The contagiousnesss of tetanus, which had long 

 been suspected from clinical observation, has been 



