Mlcrohic Diseases Individually Considered. 333 



form in certain marshy regions of Roumania, where 

 it causes the loss of large numbers of oxen. Cows 

 are less susceptible while calves seem to be refractory. 

 It is characterized by the presence of albumen and 

 haemoglobin in the urine ; the latter is red colored 

 but does not contain blood corpuscles. The autopsy 

 reveals the presence of interstitial extravasations and 

 ulcers of the fourth stomach and duodenum. The 

 tissue surrounding the kidneys is infiltrated with 

 blood and serosity, the kidneys are friable and dark 

 red in color and their pelvic mucous membrane 

 ecchymosed; the bladder is filled with red colored 

 urine. The liver is tumefied and discolored, the 

 spleen enlarged and darkened and the pulp difiluent. 



Babes has discovered in this disease a rounded mi- 

 crobe 0.5/^ in diameter, usually arranged in pairs, 

 sometimes in tetrads; it is decolorized by the Gram 

 stain. It is found in the blood adhering to the red 

 blood corpuscles or situated in their interior, but more 

 especially in the serosity of the hemorrhagic oedemas 

 and in the vessels of the kidney. It also exists in 

 the vessels of the intestinal ulcers. The invaded red 

 blood corpuscles are more or less altered. 



The rabbit, by inoculation of the blood or oedema- 

 tous liquid, as well as by ingestion of the products 

 of the disease or its cultures, contracts a general dis- 

 ease which often terminates fatally. In the ox, the 

 introduction into the veins or connective tissue of a 

 considerable quantity of blood or of juice expressed 

 from the kidneys, reproduces the typical disease with 

 hsemoglobinuria.* 



* [In many respects similar to this hsemoglobinuria of cattle and 

 to a closely allied disease of sheep (" Carceag ") also investigated 



