of the University of Pennsylvania. 25 



On the following morning, however, our atten- 

 tion was called to the condition of five out of the 

 eight men above mentioned. A rather violent diar- 

 rhoea had followed in from ten to twenty hours 

 after the administration of the drug, attended by 

 much griping and a rather unusual amount of con- 

 stitutional depression. Each of these five men. had 

 passed in the twenty-four hours succeeding the ex- 

 hibition of the drug from eight to fifteen stools. 

 These stools at first resembled those of calomel, but 

 eventually became yellow. Appropriate treatment 

 was administered, and on the following day the 

 diarrhoea was partially or wholly checked, and the 

 cases progressed favorably to recovery. It is worthy 

 of note that in each case the first few stools con- 

 tained minute particles of the yellow sulphate, 

 showing that not only had its elimination by emesis 

 been far from complete, but also that the drug had 

 been for from ten to twenty hours in contact with 

 the tissues and fluids of the digestive tract. 



In the fifth case, John H., a German, set. 38, 

 complained of a soreness of his gums, and of the 

 large amount of saliva dribbling from his mouth. 

 He had up to this time received no preparation of 

 mercury for several months. An examination 

 showed the gums to be soft and spongy, with the 



