82 Notes' from the Physiological Laboratory 



Upon one person a control-experiment was insti- 

 tuted in the following manner: Upon his right arm 

 were placed four drops of strong nitric acid, while 

 upon the same point on his left arm was similarly 

 disposed the'sarne quantity of the mixture of nitric 

 acid and cocaine hydrochlorate. The pure acid 

 caused great pain, and was speedily removed ; the 

 mixture, which was applied later, caused a sensation 

 described as "tickling, with slight pricking," which 

 soon passed away. 



In two cases the burned points were covered with 

 absorbent cotton wet with a two per cent, solution 

 of cocaine salicylate, a salt which we have not yet 

 seen described, but which, in addition to the pecu- 

 liar properties of its contained alkaloid, appears to 

 be somewhat antiseptic. There has been no discom- 

 fort after the formation of the eschar. Prof. Harri- 

 son Allen, to whom we presented a portion of our 

 solution of the salt last mentioned, kindly reports 

 that he has applied it several times in his practice 

 as a substitute for other salts of cocaine, with good 

 results. 



