of ike University of Pennsylvania. 85 



relieved during a similar attack by the method 

 already described. 



CASE V. Male, at. 34, suffering with severe 

 rheumatic pains in left shoulder. 



Thirty grains of salicylic acid were rubbed up in 

 olive oil, gently smeared upon the left side of the 

 abdomen, and covered with rubber-cloth. Here, as 

 in the other cases, the urine was tested for the drug 

 in question at the time that the application was 

 made, with negative results. Urine passed in one 

 hour and ten minutes thereafter gave, upon the ap- 

 plication of the ferric chloride test, the response 

 characteristic of the presence of salicylic acid ; and 

 this reaction was observed in several samples of 

 urine from this patient up to the thirty-sixth hour 

 after the application was made. In twelve hours 

 the rheumatic symptoms were greatly relieved, and 

 they entirely disappeared within twenty-four hours. 



CASE VI. 1 Dr. F., set. 29. Rheumatic swell- 

 ing of right knee, the circumference of which was 

 one-third greater than that of its fellow. Patient 

 gave history of previous persistent rheumatic at- 



1 We are indebted for the report of this case to the cour- 

 tesy of Dr. William Gray, who pursued the method indi- 

 cated at our suggestion. 



