146 PATHOLOGY 



for some time; the animal died on the thirtieth day, with symp- 

 toms of general debility. The autopsy showed the apices of both 

 lungs dark red, and moderate swelling of some of the glands of the 

 thoracic cavity. The mucous membranes of the pharynx and larynx 

 were inflamed ; the neighborhood of the vocal cord was covered with 

 mucus in which a small number of tubercle bacilli could be de- 

 monstrated. 



The second animal developed considerable fever about the tenth 

 day, which also lasted for a long time. After 40 days, conjunct- 

 ivitis appeared in both eyes, this gradually becoming so violent as 

 to destroy vision entirely; death resulted on the fifty-sixth day 

 after the injection, and as in the case of the first animal, seemed 

 to be due to weakness. The organs of the thorax and abdomen 

 were found normal, excepting that the left lung contained a very 

 small pea-sized tubercle, in which a few tubercle bacilli were de- 

 monstrable. None of the other organs contained anything abnormal. 



In neither of these cases are we permitted to speak of infection, 

 as in the first place, the duration of illness was too short, and in 

 the second place, the tuberculous lesions so slight that they could 

 be found only with difficulty, and it goes without saying that in 

 the short time having elapsed between injection and death the 

 tubercle bacilli introduced into the organism could still have been 

 alive. 



The rest of the calves, 12 in number, were killed after from 101 

 days to 327 days, but in no instance could a trace of tuberculosis 

 be found. 



The number of calves and heifers used for these experiments was 

 altogether 71; of these 52 were purely native animals and 19 had 

 descended from mixed races. 



The tubercle bacilli from the pure cultures as well as from the 

 tuberculous organs before being utilized for the experiments, had 

 been inoculated into guinea-pigs to note whether or not their viru- 

 lence was great enough. All of the guinea-pigs perished after the 

 usual lapse of time of typical tuberculosis. 



From the results mentioned, the following conclusions can be 

 drawn : 



(1) Human tuberculosis is as frequent in Japan as in the civil- 

 ized countries of Europe and America. 



(2) Primary intestinal tuberculosis is relatively common in adults 

 and children, although cow's milk plays no r61e at all in the feeding 

 of children. 



(3) There are large districts in Japan, where, in spite of the 

 existence of human tuberculosis, the cattle remain absolutely free 

 from the disease. In these regions it is not customary to consume 

 either meat or milk from bovines. 



