HENLE'S OPINION REGARDING IT. 117 



the circumstance might be explained by conceiving that two (or more) 

 contiguous nucleoli, with their layer of granular deposit, had fused 

 together before either of them had attained such a stage of development 

 as singly to constitute a nucleus. And in those cases in which the nucleus 

 of a cell appears to consist of two or more portions, he inferred that the 

 component parts were so many nuclei which had been contiguous to each 

 other, and fused together before the growth of the cell-wall around each 

 had made much progress. 



According to Henle* the formation of cells takes place in three 

 different ways ; in two of these (which appear to be only modifications of 

 each other) the nucleus is developed first, while in the third it is not 

 formed until after the cell, or even does not appear at all. In whichever 

 of these ways the cells are developed, numerous spherical or oval fat-like 

 particles first make their appearance in the cytoblastema or formative fluid. 

 In one of the three modes of development, a layer of the dimly-granular 

 material of the cytoblastema appears to deposit itself upon one of these 

 fat-like particles, and thus to form a nucleus, upon which a cell-wall then 

 grows, though, as will be noticed again presently, in a manner some- 

 what different from that pointed out by Schleiden and Schwann. In 

 another mode, the nucleus is formed by the grouping together and 

 coalescence of two, three, or even four of the elementary particles; a 

 cell-wall is developed around this compound nucleus in the same manner 

 as around the simple one. As the growth of the cell proceeds, the com- 

 ponent particles of the nucleus become completely fused together, and a 

 single smooth body eventually results. The compound nature of the 

 nucleus of epithelial cells, and of pus-corpuscles after being acted upon by 

 water or dilute acetic acid, is by Henle attributed to the fact of such cells 

 being examined at an early period of their growth, and previous to the 

 complete coalescence of the several particles composing the nucleus. f 

 Henle believes that this mode of development prevails among most 

 elementary cells of the animal body, and he refers, in illustration of it, 

 to the corpuscles of mucus and pus,J to those of the lymph and chyle, and 

 to the cells of most glandular structures. With regard to the mode of 

 production of the cell-wall around the nucleus, Henle is of opinion, with 

 other physiologists, that the several elementary granules are so many par- 

 ticles of fat, and that around each one, or a group of them (according as 

 the nucleus happens to be simple or compound) a layer of the albuminous 

 matter of the cytoblastema coagulates and forms a kind of film or 

 coating, in accordance with the fact pointed out by Ascherson, that 



* Allgemeine Anatomie, pp. 152 162. 



f Kolliker, as will be presently mentioned, offers a different explanation of this appearance. 

 I Vogel also describes the development of pus in the same way. (Miiller's Physiology, 

 p. 466; and Pathologische Anatomie des menschlichen Kbrpers, 1845, p. 90.) 

 Miiller's Archiv, 1 840, Ueber die physiolog. Bedeutung der Fettstoffe, &c. 



