IN the autumn of 1894, after Roux's publication of 

 the first decisive experiments with Bchring's sero- 

 therapy applied to diphtheria, the production of anti- 

 diphtheric serum was eagerly taken in hand everywhere. 

 In Denmark, too, the first introductory steps were made, 

 at that lime, towards the foundation of the Serum Insti- 

 tute, which to-day is an accomplished fact. As the direc- 

 tor of the University Laboratory of Medical Bacteriology 

 I felt it my duty to study more thoroughly the technic 

 of the production of antidiphtheric serum. So, in Sep- 

 tember 1894, I went to the Pasteur Institute, the only 

 laboratory where for years they had both been work- 

 ing at the manufacture of serum and allowed other 

 people to share the experience they had gained. Imme- 

 diately after my return, I sent in a petition to the Minis- 

 try of Ecclesiastical and Educational Affairs, asking that 

 an extra grant of kr. 10000 should be made in the bud- 

 gel of 1895 90, to enable the Laboratory to make sero- 

 Iherapeulic experiments, while it, at the same time, 

 undertook 



1st to have in view, as far as possible, during the ex- 

 periment, the production of great quantities of 

 anti-diphtheric serum; 



