Ill 



G obs. continually decrease with increasing n. There 

 is therefore no reason for drawing the G curve (the 

 previously so called "toxinspectrum") as a line, formed 

 like stairs, this would also be very improbable from a 

 theoretical point of view. It was owing to the great 

 errors of experiment and especially the very complicated 

 composition of a deteriorated diphtheria toxin which 

 caused the first curves of toxicity to take this form. 



Kig. 4. 

 Neutralisation of telanolysin bv antitoxin 



t observed values. - toxic quantity 



X - - - toxicity 



This curve of toxicity is very like that, which repre- 

 sents the equilibrium between a body in partial disso- 

 ciation and its products of dissociation. The formula 



[Free toxin] (Free antitoxin]_ (combined toxin-antitoxin] 3 

 ~ ~ 



has been used for the calculation of G. The calcula- 

 tion of the free and combined toxin has been made in 

 the following manner. The original mixture of toxin 



- 59 



