Ill 



Table 18. The action of old tetanolvsine. 



decreased to about one sixth, which shows that a trans- 

 formation of the molecules of toxin has taken place. 

 This probably depends on a very little change of the 

 molecules of toxin, perhaps a transformation to a meta- 

 meric compound, less toxic. To examine this an in- 

 vestigation of the time, taken by this process in the 

 case of toxins of different concentrations would be of 

 great interest. 



By this transformation the constant of dissociation, 

 K has only been influenced to - a small extent, having 

 increased from 1,18 to 1,74, viz. by about 50%. This 

 circumstance brings about, that by the same amount 

 of antitoxin the toxicity of the old tetanolysin is not 

 diminished in the same proportion by the same amount 

 of antitoxin as the fresh tetanolysin. According to the 

 calculated ciphers, without doubt much less faulty than 

 those directly observed, the toxicity of fresh and old lysin 

 with the following additions of antitoxin - - is diminis- 

 hed to the values indicated in the second and third 

 columns (Tp. 37 C.). 



