VI 



7 a 9 1O il 12 13 /* fS /# t7 18 13 2O 21 12 



. it 29 30 31 1/ f 2 3 * 5 S 7 S 9 10 11 12 13 1* 15 1f 17 IS 19 2O if 22 



Curve No. 5 



of injecting a single large dose of culture, a compara- 

 tively little quantity of a 2/ih culture was injected daily 

 during a longer period. Examples are given in the cur- 

 ves 2 and 3. 



The goat, referred to in curve 2, showed a slow 

 decrease in agglutinating power during the months, 

 following after the last injection of B. typhos. culture 

 on the 4 / 8 ; at about 40 equilibrium occurred. From the 

 8 / 12 to the 31 / 13 5 cc. of a 24h B. typhos culture was daily 

 injected on the animal, alltogether 120 cc. Its state of 

 health seemed not to be influenced upon under this 

 treatment. During the first 5 days the agglutinin remai- 

 ned in the previous plan of equilibrium, but then increa- 

 sed rapidly to 555 on the 27 /i2- From this day a conside- 

 rable fall occurred in spite of the injections, which were 

 still going on during the 3 following days until the 3l / n . 



On curve 3 is given an analogous experiment with Vb. 

 chol. culture, and quite correspondent results were found. 



17 



