VI 



These two doses contained exactly the same amount 

 of agglutinin. On the 24 /e goat III got 20 cc. of the same 

 rabbit serum and No. IV 7 cc. of the same goal serum. 

 Before the experiment slight traces of agglutinating power 

 could scarcely be demonstrated in the serum of No. I 

 and II, while No. Ill and IV had a little more, viz. 0,3 

 and 2. It appears, that after the injection the serum of 

 No. I and II reached exactly the same amount of agglu- 

 tinin, 8, and that the curves thereafter were running 

 quite parallel during 47 days, when the blood still con- 

 tained recognizable quantities of agglutinin. As to the 

 other two animals corresponding results were obtained. 

 No. IV died on the 17th day of an accidental infection, 

 when its serum had a strength of 18 and No. Ill, injected 

 with rabbit serum showed increased agglutinin reaction 

 14 days after the injection. 



The last series of experiments makes it clear, that 

 the fate of the agglutinin from rabbits and goats is quite 

 identical, when introduced into the fluids of goat in 

 corresponding quantities, but that quite other phenomena 

 occur in the organism of rabbits. Thus it is not pos- 

 sible to set up a general law for the fate of the agglu- 

 tinin of one species within the fluids of another, but 

 each single case requires a special examination. 



The disappearance of the agglutinins from the organism, 

 on which they are injected, is very like that of the te- 

 tanus- and diphtheria antitoxin, as it is found by several 

 investigators (Behring, Bomstein, Bulloch). 



It is not easy to decide if the agglutinins may be 

 considered as simply diluted in the blood, into which 

 they are introduced. One of the difficulties is the exact 

 determination of the quantity of blood in the animal 



26 



