VI 



imum on the 7th 13th day after the injection 

 (usually 9th-llth day). 



3 phase. A decrease, commencing rapidly and 

 gradually passing into 



4 phase, where a very slow fall occurs or an 

 equilibrium is reached. 



2) A similar curve is obtained in the case of a fresh 

 animal, never treated before. 



3) Daily injections of small amount of culture will 

 produce a similar curve. The rise, followed by 

 the fall, will occur during the injections. 



4) It is probable, that the production of antibodies gene- 

 rally has the type, first described by Brieger and Ehr- 

 lich in the case of immunisation against tetanus. 



5) Agglutinin, injected into the circulation will disap- 

 pear rapidly at first and later on more slowly. 



6) Agglutinin from goat disappears quickly from the 

 circulation of cat and rabbit, while agglutinin from 

 rabbit keeps for a comparatively long time in the 

 blood of rabbit. 



Agglulinin from rabbit and goat, introduced to a si- 

 milar amount in the circulation ot the goat, will keep 

 for quite the same time. 



A difference between agglutinin from goat and rabbit 

 may possibly be supposed. 



It is impossible to lay down a general law for the fate 

 of the agglutinin of one species in the fluids of another. 



7) The agglutinins may be considered as simply diluted 

 in the blood, into which they are introduced. 



8) The introduction of typhoid or cholera serum into 

 an organism (thus passively immunised) will pre- 

 vent the typical agglutinin curve, which is regu- 

 larly produced in an actively immunised organism 

 by an injection of culture. 



39 - 



