VIII 



Goat curve No. III. 



Il/l,inj.of40cc. 24 h b. 6/2 13/3, daily inj. of 5 cc. 24 h 

 Vb. chol. culture Vb. chol. culture 



These four examples refer to the fall (third phase), 

 observed in goats, which were actively immunised in 

 different ways against B. typhos. or Vb. choleric. The con- 

 cordance between the calculated and observed values is 

 so exceedingly good, that without doubt the conclusion 

 can be drawn, that the decrease of antibody during ac- 

 tive immunisation can be expressed by the same for- 

 mula, as that applied to passive immunisation. 



Accordingly the fate of the agglutinin in an actively 

 immunised organism may be conceived in this way: 



After a single injection of culture an incubation pe- 

 riod is first observed. Then follows the period during 

 which the agglutinin is brought into the circulation 

 slowly at first, then more rapidly and later on slowly 



- 10 



