In works dealing with pathogenetic forms of yeast no 

 mention is made, as far as I know, of the changes 

 that occur in the tissues at the point of inoculation at 

 the time immediately after the inoculation. I have now, 

 at the suggestion of Professor Salomonsen, taken this 

 question in hand. 



Earlier investigators have wailed till the death of 

 the inoculated animals before making their resear- 

 ches, or, if death did not result, they have confined 

 I hemselves to the examination of the nodules in an advanced 

 stage of development. The fact that these nodules are 

 generally called ,,tumors", although it is acknowledged 

 that the greater part of them consist of yeast lying 

 in a mesh of connective tissue, makes it all the more 

 desirable that they should be examined more closely. 



Sanfelice gives, in his first paper on Saccharomyces 

 neoformans (Zeitschrift fur Hygiene, vol. XXI p. 40), 

 the following account of a microscopical examination 

 of the nodules. ,,Die Geschwiilste . . . lassen ein Netz 

 von jungem Bindegewebe erscheinen in dessen Maschen 

 sich hier einige wenige, dort zahlreiche zellige Elemente 

 finden, welche Lymphkorperchen ahnlich sehen, und deren 

 Kern meist an die Peripheri des Zellkorpers gedrangt 

 ist. Neben diesen Elementen kommen so zahlreiche 

 Parasiten vor, dass man sagen kann, die Geschwulst 



3 ^ 



