X 



werde vielmehr durch die parasitaren Elemente als durch 

 Gewebe gebildet. 



An einigen Stellen sind die Zellenelemente haufen- 

 weise neben einander gclagert, und einige haben inner- 

 halb ihres Korpers junge Parasiten eingeschlossen. Die 

 Kerne der Zellenelemente sind meist rund und zeigen 

 keine Andeutung der Fragmentation. 



Der grosste Theil der Parasiten liegt frei, und einige 

 von ihnen sind gut gefarbt, andere erscheinen hyalin 

 ohne Spur von Farbung." 



Page 47: Jn der Haut, welche die Geschwulst des 

 Unterhautbindegewebes bedeckt, und in den unter dem- 

 selben gelegenen Muskeln konnte ich keine Verander- 

 ungen bemerken." 



I have myself during the last few years made a 

 great many inoculations into guinea-pigs and rabbits 

 with different pathogenetic yeasf forms. These experi- 

 ments will be published elsewhere. Here, where I 

 intend to deal exclusively with histological changes at 

 the point of inoculation in order to gain insight into 

 the development of the yeast nodules, I shall only call 

 attention to a few of these earlier results: The nodules 

 at the point of inoculation are rarely larger than dates, 

 often smaller; this size is reached after a little more 

 than a fortnight; about three weeks after the inocula- 

 tion the outer skin died away and pealed off like a 

 scab leaving an open wound with thickened edges and 

 ground; this wound might heal, leaving a rather large 

 flat, hairless scar, that is, if the animal had not died 

 at the inoculation; this happened very seldom. 



The weight of the animal remained the same or only 

 increased a little during the first few days until the 

 sixth or seventh day, when it commenced to decrease 

 at the same time as the lymph nodules in the groin 



- 4 - 



