yeast cells were found in the connective tissue under 

 the skin and in the upper layers of the fascia. Here 

 the greater part of them were lying in a heap of about 

 1 ctm. in width and not quite 1 mm. in thickness; some 

 had spread in a thin layer, most of them descending 

 towards the central line. 



Guinea-pig 1 (3 l /% hours). 



At the point of inoculation in guinea-pig 1, which 

 was killed three hours and a half after inoculation, 

 the protuberance produced by the injection, the size 

 of half a hazelnut, was seen still unchanged. On 

 section, there was also found an oedematous thicken- 

 ing of the connective tissue of the leather-skin at 

 the point of inoculation. The yeast cells, lying in a 

 compact heap in the connective tissue, look as if they 

 had been left by filtration on the spot where the point 

 of the syringe was. Among these cells a few threads 

 of connective and elastic tissue may be pointed out. 



Round all the veins, whose outlines are clearly tra- 

 ced by means of elastiu staining, a great many polynu- 

 clear leucocytes are seen; similar ones are seen in con- 

 siderable numbers inside the vessels. Most of the leu- 

 cocytes are found on the side turning towards the heap 

 of yeast cells (see the affixed table Fig. 1). Evidently 

 a lively emigration of the polynuclear white blood-cor- 

 puscles has already taken place, and some of them have 

 reached the yeast cells. The emigration is greater from 

 the veins of the leather-skin than from those lying 

 between the muscles, though it may also be seen in 

 the uppermost layers of the latter. Thus the greater 

 number of the leucocytes are found on the external 

 side of the yeasl heap. On staining the cells by the 

 common methods most of them prove not to be granu- 





