X 



Guinea-pig 2 (6 hours} and 3 (8 hours}: 



In the sections from guinea-pig 2 (six hours) and 3 

 (eight hours) similar changes as in 1 are found. How- 

 ever the oedema had somewhat decreased, but is still 

 perceptible as a distension of the connective tissue of 

 the leather-skin. The number of the emigrated white 

 blood-corpuscles found in the neighbourhood of the ves- 

 sels is not so great; they are moving towards the yeast 

 cells, or have already reached them, having advanced 

 more forward into the heap where they stuff themselves 

 with yeast cells. There are still only very few granular 

 leucocytes. The cells of the connective tissue are un- 

 changed, and yeast cells are affected by stains as in 

 guinea-pig 1. 



Guinea-pig 4 (18 hours}: 



In guinea-pig 4 (eighteen hours) nearly the whole of 

 the yeast heap is seen penetrated and, for the greater 

 part, ingested by the leucocytes. The yeast cells do not 

 all of them retain a regular round form; several of 

 them are angular or starshaped; they are no longer 

 stained in the regular way by Claudius' method. 



Now all the yeast fungi in the thin lateral and me- 

 dian edges of the yeast heap are ingested by wander- 

 ing cells; the oedema has disappeared; and in the ves- 

 sels the number of leucocytes has diminished. 



In a few places in the connective tissue, and excep- 

 tionally between the leucocytes that are filled with 

 yeast, round cells may be seen. They have a single, 

 great, oviform, cystoid nucleus, which is somewhat lobu- 

 lar; very little protoplasm which takes a brown stain 

 by van Gieson. I have not been able to find any gra- 

 nules in them. These cells are not seen in the neigh- 



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