X 



The number of mononuclear cells has greatly increa- 

 sed; several of them are fusiform; they may very filly 

 he called ,,fibroblasts". 



Guinea-pig 7 (3 days) and 8 ('i days): 



In guinea-pigs 7 and 8, which were killed after three 

 and four days respectively, the said changes were still 

 more clearly pronounced. The yeast cell heap was 

 surrounded and permeated by a great many long, fusi- 

 form cells. Beside these there were seen, on using 

 van Gieson's stain between the yeast fungi, a few con- 

 nective tissue threads and, on staining with elastin, a 

 very few elastic threads appeared. The latter looked 

 as if they were not destroyed, wholly preserving their 

 normal appearance. 



The number of tissue yeast cells has increased. In 

 many places enlarged cells, which have altered with 

 respect to staining, appear, all stages from culture yeast 

 cells to tissue yeast cells being represented. Moreover 

 forms of gemmation are found in no small number, 

 sometimes quite irregular as moderately long threads. 

 Many of these large cells have a distinct capsule with 

 radial stripes, not seen on the yeast cells in older 

 nodules; these stripes are made more perceptible by fibrin 

 staining, which also sometimes makes a dark coloured 

 ring appear round the capsule. Capsules are not found 

 in all tissue yeast cells. 



Guinea-pig 9 (5 days): 



Five days after inoculation we meet a fresh stage. 

 A great many tissue yeast cells are found here, most 

 of them having capsules, many being gemmiferous. 

 They are lying in a tissue of fibroblasts. The yeast cells 

 found in the phagocytes now appear as small (2 3 p.), 



- 12 



