X 



angular, starshaped or half-moon shaped remnants stain- 

 ing very irregularly. 



On this stage we find in the yeast heap a great 

 many mononuclear large cells whose protoplasm is 

 filled with a great many small vacuoles. This pheno- 

 menon is not easily accounted for. Most likely the 

 vacuolation is due to a poisonous action; but in many 

 cases it may. be the result of a phagocytosis which has 

 come to an end. The fact that corpuscules representing 

 all transitory forms up to unmistakable yeast cells are 

 sometimes found in the vacuoles (s. Fig. 7), speaks in 

 favour of this hypothesis. 



No less difficult to explain is another observation 

 made on this stage, viz. the position of the yeast cells 

 with regard to the fibroblasts that surround them. In seve- 

 ral places, they are lying scattered about, not as before in 

 immediate contact with the latter; for on the sections 

 the small yeast heaps are seen separated from the sur- 

 rounding fusiform cells by clear zones which, on celloi- 

 din sections, are always filled with celloidin, making 

 it likely that in life they were filled with a fluid (s. Fig. 2). 



There are no connective tissue threads among the 

 fibroblasts; but a considerable number of mitoses show 

 that the peripheric fibroblasts multiply at a great rate 

 (s. Fig. 4). The cells produced by this division differ 

 from the mononuclear cells mentioned above by having 

 larger, more darkly stained nuclei, and a protoplasm 

 which takes a deeper stain. Now five days after 

 inoculation , the lymph nodules in the correspond- 

 ing groin have become palpable, and their size, on 

 section, is 2'/ 2 and 2 mm. respectively. In the lar- 

 ger one, situated nearer to the inoculation point, a 

 number of yeast cells with a pronounced thick capsule 

 are placed near the surface. They are all free. In the 



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