X 



small lymph nodule no yeast cell is yet to be found. 

 Its swelling seems due to the absorption of soluble 

 toxic secretions or products of decay, whilst the yeast 

 cells are still retained in the former. 



The yeast cells easily spread themselves along I he 

 lymph passages. This is seen also from the fact that 

 in several places, often rather far oil from the point of 

 inoculation, small heaps of yeast fungi are located in 

 the neighbourhood of small arteries, as a rule betwecMi 

 these and the corresponding veins. Sometimes the 

 yeast cells form a sheath round the artery, the cells 

 making the impression of lying in a hollow existing 

 beforehand. 



Guinea-pig 10 (6 days) and 11 (8 days,): 



After six and eight days the changes mentioned 

 above continue. The yeast cells multiply; the clear 

 spaces already described grow larger; the culture yeast 

 cells go on decaying, disappearing entirely in some 

 places. Among the fibroblasts a line mesh of connec- 

 tive tissue threads is found, especially near the edges. 

 Gradually all the yeast cells have become surrounded 

 by a ring of fibroblasts and new connective tissue. In 

 several places this ring sends down runners between 

 the muscles. These runners partly enclose the single 

 muscular fibres, some of which are clearly thinned and 

 seem on the point of disappearing. The lymph nodules 

 have grown a little, but yeast cells are still only found 

 in that one nearest to the point of inoculation. In 

 these two guinea-pigs the milt, the lungs, the liver and 

 the kidneys were subjected to microscopical examina- 

 tion. Neither yeast cells nor morbid changes were 

 found in the tissues. 



- 14 



