X 



Guinea-pig 12 (20 daysj: 



In guinea-pig 12. which was killed after twenty 

 days, the changes have grown still more pronounced, 

 the skin, however, has not yet been attacked. On the 

 point of inoculation is found a protuberance whose 

 dimensions, on section, are about 3X1 l / z ctm. In the 

 centre of this nodule appear innumerable yeast cells of 

 very different sizes varying from 5 32 p. placed in a 

 hollow, most likely filled with a fluid, in which a few 

 connective tissue threads may be seen but no elastic 

 threads. Only a very few tissue cells are found, most 

 of which having the characteristic vacuolised proto- 

 plasm described above with oval nuclei near the sur- 

 face. A connective tissue growing firmer towards the 

 outside, is seen round this typical mass of yeast. 

 The central hollow space filled with yeast cells is, no 

 doubt, due to a junction of several smaller hollows, 

 partly in the leather-skin, partly down among the mus- 

 cles. There are also some small nodules, on the whole 

 similar in structure to the greater ones. 



Leucocylic infiltration appears nowhere, not even 

 round the vessels. 



In this guinea-pig the lymph nodules are enlarged, 

 about the size of peas. The first is entirely permeated 

 by yeast cells; a smaller number is seen in the second; 

 the third, of the size of a hempseed, is still without 

 any at all. Yeast cells are found in the lungs, the milt 

 and, in small numbers, in the kidneys, but I shall not 

 here go into particulars with regard to the changes which 

 take place in the inner organs of the animals. 



Guinca-piy 13 (35 daijsj: 



This" guinea-pig, which was killed thirty-five days af- 

 ter inoculalion. illustrates how the continuous growth 



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