X 



of the yeast cells has produced an atrophy of Ihc 

 covering skin, while the scab begins to be thrown 

 off. Otherwise the appearance is exactly the same as 

 with guinea-pig 12: great heaps of yeast located in 

 a very loose connective tissue whose meshes look as 

 if they were extended by a fluid. Downwards towards 

 the atrophic abdominal muscles the nodule is limited 

 by a firmer connective tissue capsule. 



At the same time as the scab is thrown off, the 

 greater part of the yeast cells will, as a rule, empty 

 themselves as a pulpy mass, and the great loss of sub- 

 stance thus caused will generally heal in the course 

 of a few weeks, the animal increasing in weight and 

 making a complete recovery. 



It is very doubtful, however, whether this guinea- 

 pig would have escaped death, as guinea-pigs generally 

 do after subcutaneous inoculation. In this animal, the 

 penetration of the yeast cells into the blood passages 

 through a venous wall was distinctly seen an occurrence 

 I have observed in this one animal only of the great 

 number that I have made the objects of careful micro- 

 scopic examination. 



In one place of the venous wall the elastic threads 

 had been burst and disjoined by the invading yeast 

 cells, which over a certain area entirely filled the vessel, 

 while they, on other points, were covered by a throm- 

 bus. An examination of the inner organs of the animal 

 showed that the yeast cells had already reached the 

 liver and lungs, lying sparely spread inside all over 

 the vessels, particularly numerous in the lungs. 



In the groin there were three swollen lymph no- 

 dules. Two of them, of the size of a pea, contained 

 a great many yeast cells. The third was about the size 

 of a hempseed showing only a few parasites. 



