which are lying in a tissue of fibroblasts in the cha- 

 racteristic way described above : They make the impres- 

 sion as if they were lying in hollows which, in life, 

 must be supposed to have been filled with a fluid. At 

 the same time the fibroblasts multiply by indirect divi- 

 sion, and especially on the fifth day a great many karyo- 

 kinetic figures were seen |s. Fig 4]. 



Moreover, fine, new connective tissue threads are 

 now perceptible. Whilst the injected n ciiUurc yeast 

 cells" produced a violent acute inflammation with an ac- 

 tive emigration of leucocytes, no anatomical changes of 

 the kind are found later on during the quick growth 

 of tissue yeast cells. 



On the whole ,,the tissue yeast cells" seem to be acting 

 chiefly in a mechanical way on the surrounding tissues. 

 As soon as the greater part of the culture yeast cells 

 have been ingested by the phagocytes the emigration 

 stops, and most of the supervenient changes may well 

 be explained as due to nothing but the increase in 

 number of the yeast fungi. It is, however, natural to 

 suppose that they affect the surrounding tissues in a 

 chemical way as well, even though this occurrence was 

 not very evident in the method of experimenting used here. 

 The characteristic vacuolisation of mononuclear cells as 

 described above, may perhaps be looked upon as the 

 result of a poisonous action. 



Rather early - - on the fifth day yeast cells may 

 be shown in the lymph nodules next to the point of 

 inoculation. Later on, their number increases greatly, 

 and they propagate from one lymph nodule to the 

 nearest one. Some swelling of these lymphatic glands 

 is, however, always seen before the yeast cells can be 

 pointed out. It is impossible from what has been said 

 above to decide whether this fact is due to a toxic 



18 



