DEVELOPMENT OF TH K Ai.HIXO I: \ I 49 



toward the mesometrial border of the uterine horn, while its 

 thinner portion is designated as its roof, directed toward the 

 ant i mesometrial border. Therefore, in slightly older stages 

 than thus far figured, the vesicle lies with its long axis approxi- 

 mately at right angle to the long axis of the uterine horn. In 

 further description of the blastodermic vesicle, I shall use the 

 term 'floor' and 'roof as here specified. In D and E of figure 20, 

 there are reproduced typical sections of the two blastodermic 

 vesicles taken from the uterus of rat No. 68, killed 4 days, 10 

 hours after insemination. Vesicle D measures 90 fi by 30 n 

 by approximately 60 m. and is of distinctly ovoid form and 

 slightly compressed. This vesicle is found lying free in a long 

 but narrow fold of the mucosa, both sides of which are slightly 

 molded in conformity with the form of the vesicle. The 1 long 

 axis of the vesicle is still parallel to the long axis of the uterine 

 horn. The roof of the vesicle appears as if slightly contracted, 

 though when traced through the series of six sections it does 

 not appear folded. The roof is composed of only a few cells, 

 perhaps seven in all. The segmentation cavity presents a regu- 

 lar outline. This vesicle supports the contention of Widakowich, 

 that the form of the blastodermic vesicle of the rat is dependent 

 in a measure on the form of the space in which it is found. Vesi- 

 cle E, of figure 20, measuring 85 ^ by 45 n by approximately 

 40 fx, presents a roof that is slightly folded and shows an early 

 stage in segmentation cavity formation. A figure of the vesicle 

 is included since it represents more clearly than any other blas- 

 todermic vesicle of the albino rat in my possession, a differentia- 

 tion of a layer of surface cells in the mass constituting its floor. 

 This is a question to be more fully considered in further discussion. 

 In all the measurements of blastodermic vesicles thus far 

 given, even in those given for the morula mass shown in A, figure 

 20, it is evident that one of the short diameters is appreciably 

 shorter than the other. The vesicles are not only of ovoid form, 

 but slightly flattened, so that even when not folded, the form of 

 the vesicle as seen in section, even when cut parallel to the long 

 axis of the respective vesicles, is dependent in a measure on the 

 plane of the section, whether parallel to the longer or the shorter 



