ON SPECIFIC THERAPEUTICS. 19 



these groups are independent of each other, is 

 well seen in the case of modified complement 

 "complementoid," as numerous test-tube experi- 

 ments have proved. Of special interest are the 

 conditions of their distribution. The real state 

 of affairs, which has been thoroughly investi- 

 gated, especially in the case of haemolysins, is 

 this : the intact erythrocytes do not unite with 

 the complement, which, however, is anchored 

 by the complex of erythrocyte and ambo- 

 ceptor. A closer acquaintance with the condi- 

 tions which govern distribution in this matter, 

 cannot be arrived at by the hypothesis that 

 the erythrocyte is sensitised by the amboceptor 

 in such manner that an action of the com- 

 plement is rendered possible. If one accepts 

 the theory of Bordet, which really consists of 

 the denial of the existence of direct relations 

 between amboceptor and complement, one enters 

 the realm of pure speculation ; for one must 

 then presume new affinities between the ery- 

 throcyte and complement to arise under the in- 

 fluence of the amboceptor. For this assump- 

 tion we have no grounds. Bordet's method of 

 proof must, therefore, limit itself to indirect 

 conclusions, and consists merely of objections 

 to the view held by Morgenroth and myself, 



c 2 



