CVIII BOWMAN LECTURE. 



small smoker, epileptic, takes bromide). The age of 

 onset was as follows: I, 1 about 25 ; 25 in III, 1, 5, 8, 

 IV, 7 and 9; 26 in IV, 13; 30 in III, 8; 31 in IV, 14 ; 

 17 in V, 2; 41 in IV, 5. No early deaths. Descent 

 strictly according to rule. Of the 12, 8 had no children 

 and apparently did not marry ; the 4 who married had at 

 least 20 children between them. As to present age, IV, 

 14 is now (J909) 42 ; IV, 13, 41 ; IV, 9, 29. I, 1 died at 

 a ripe age, about LOO years ago. No consanguinity. 



1898. (Fig. 48, inserted at p. Ixii, supra,) Klopfer, 

 Inaug. Dissert. Tubingen. 



The J in VII (author's Case 5) reported to have had 

 the same disease. In VIII (counting from the left), No. 

 1 (author's Case 4) was affected at or about 20. VIII, 4 

 (author's Case 2) affected in 24th year, seen soon after; 

 three years later, no recovery; V. fingers. VIII, 5 

 (author's Case 1) affected at 21, seen six months later; 

 five years later, no recovery. VIII, 6 (author's Case 3) 

 affected in 20th year, seen three years later. Much con- 

 sanguinuity, but disease probably derived through VI, 23. 



1884. (Fig 49.) Norris, T.A.O.S., iii, p. 662. 



Four generations, 14 cases. I, 1 female, no details, but 

 family records seemed trustworthy. II, 1 affected at 14, 

 died 45 ; his first-born (III, 1), 45' at date of record, normal, 

 had two children (IV, 1 and 2) of whose sight nothing- 

 known ; second son, III, 2 affected at 18, died at 22. II, 2, 

 normal, five children; III, 3 affected at 15, died childless 

 at 50; III, 4 affected at 35, living, aged 50 at date; III, 

 5, 48 at date, and her husband, examined and found quite 

 normal ; they were not consanguineous ; III, 7 normal, 

 childless at 40; III, 8 affected at 19, aged 40 at date; 

 two sons (IV, 14 and 15), aged 6 and 3 at date and normal. 

 IV, 3, affected at 18, died at 30; IV, 4, affected at 14, 

 died at 18 ; IV, 5, normal, 20; IV, 6, 18, no information to 

 be got. IV, 7 to 13, issue of III, 5 and 6, all affected 

 and all examined (author's Cases 1 to 7) : IV, 7 aged 

 22 at date (author's Case 5), failed at 14, stationary 3 

 years, then improved so that she could sew, and at date 



