BOWMAN LECTURE. CXV 



eacli individual at whatever age the attack occurs. In 

 pedigrees where it comes on early, i.e., before the 

 fourteenth year, some females are usually affected ; the 

 reverse is true of the pedigrees where the onset is deferred 

 until 30 or later, female cases being found in only a few 

 of these. There seems, therefore, to be some connection 

 between early age of onset and the female sex. 



We have not much information about the longevity 

 and causes of death of those who are afflicted, but the 

 records show that a fair number were alive at 50 and 

 later, up to 75 ; one died at 69, a pair of brothers at 72 

 and 73 respectively, and one man at 86. I have lately 

 (thanks to the kindness of Mr. Doyne) seen a woman, 

 now 71 (Fig. 52, II, 2), who has had the disease since 

 birth or infancy ; whilst in another woman, seen at 75 

 by Mr. Sym, the disease did not set in till she was 51. 

 The subject is worth following up. 



Case and Fig. 52, 1898 to 1909, unpublished, kindly 

 communicated by Mr. Doyne, is a very important one. 



I, 3 had some defect of sight, but not so bad as 

 daughter (II, 2), and could do needlework and read ; it 

 may have been only myopia. Had 14 siblings (I, 2) ; 

 her first child (II, 2) illegitimate, aged about 71 when 

 seen (1909), sight failed in childhood, and has remained 

 same ever since ; symptoms and appearances characteristic 

 in her and the other cases, all of which have been seen ; 

 has been very deaf for many years. I, 2 afterwards 

 married I, 4, and had by him 2 sons and 4 daughters 

 (II, 3 and 4), who all saw well. II, 2 married apparently 

 after 30. Husband (II, 1) of about same age, after- 

 wards lost both eyes from a boiler accident. They 

 have had 4 children, who are all living ; III, 2, aged 84 

 (1909), who has one living child, IV, 2, aged 8, normal, 

 and one who died (IV, 1) ; III, 3, aged 32, normal, has 3 

 children (IV, 3, 4, 5), aged 5 years to 10 months, all 

 normal ; III, 4 seen by Mr. Doyne at 20 and by E. N. at 

 30 (1909), "born with the sight as it is now," is married 

 to III, 1, who was examined and found normal ; III, 5, 



