CXXXIV BOWMAN LECTURE. 



(3) In another group of cases a multitude of small, 

 round, whitish dots or spots of what appears to be super- 

 ficial disease of the choroid occupy the central area of 

 the fundus, and in some examples pigmentary changes are 

 described more peripherally. Mr. Doyne recorded the first 

 definitely hereditary case of this variety in 1899,* using 

 the term " honey-comb choroiditis." His patient was one 

 of several siblings similarly affected, and the disease had 

 occurred in the ascendants for three generations ; I believe 

 that Mr. Doyne has not hitherto published the genealogy 

 of this remarkable family in full. A case probably of 

 the same sort in a brother and sister had been published 

 by Mr. Langt in 1885, and a single case perhaps of the 

 same type, without record of others in the patient's family, 

 by Mr. Juler in 1893,J whilst in 1897 Mr. K. D. Batten 

 and Mr. Holthouse recorded another single case, agreeing 

 with the description of honey-comb choroiditis in a woman, 

 aged 25 years, the last born of 24 children, 20 of whom had 

 died young from some obscure cerebral disease. A case, 

 probably similar, with coloured illustration, was published 

 by Mr. Reginald E. Bickerton in 1900.|| In 1901 Mr. 

 Hugh Thompson^! put on record the case of a woman, set. 57 

 years, with extensive superficial choroidal changes around 

 the discs which had caused no symptoms; but her father 

 and three brothers who were his grandsons, i. c. were 

 nephews of the patient, were night-blind, and one of 

 them who was seen had the appearances of atypical 

 retinitis pigmentosa. 



The case given by Liebredht** as retinitis punctata 

 albescens in 1895 does not agree in all respects with that 



* Doyne, T.O.8., xix, 1899, p. 71. 



t Lang, T.O.S., v, 1885, pp. 140 and 141. 



I Juler, T.O.S., xiii, 1893, p. 143. 



E. H. Holthouse and E. D. Batten, T.O.8., xvii, 1S97, p. 62, and xx, 

 p. 95, with Plate III, fig. 2. 



II Reginald E. Bickerton, T.O.8., xx, p. 93, with Plate III, fig. 1. 

 f Hugh Thompson, T.O.8., xxi, 1901, p. 66. 



** Liebrecht, Klin. Monats. f. Augen., 1895, p. 169. The case is quoted 

 almost in full in my account of retinitis punctata albescens in R.L.O.H., 

 xvii, p. 392. 



