cur 



BOWMAN LECTURE. 



APPENDIX III. 



GLAUCOMA. 



The paper by Lawford in R.L.O.H., xvii, p. 57 (1907), "Examples of 

 Hereditary Primary Glaucoma/' contains particulars of twenty-four 

 families in which the disease prevailed, and a list of nineteen references 

 to the literature. Six of the cases are new, eighteen had been published 

 before. 



Anticipation was well marked in at least half of the series, viz., Cases 

 1, 3, 6, 7, 8, 10, 11, 13, 14, 16, 17, 24, taking them serially as they come 

 in Lawford's paper. The following seven of these were shown in 

 pedigree form at the lecture. 



Fig. 28 (Lawford, Case 7, from Lucien Howe) : 1, 4 affected at about 40, 

 and became blind; II, 2 affected at 28 ; II, 3 at 25 ; III, 1 at 28 ; III, 3 

 probably about the same age ; III, 5 at 17 ; III, 6 at 26 ; III, 8 at 19. 



Fig. 29 (Lawford, Case 1) : I, 1 blind from " amaurosis " (? glaucoma 

 simplex) for some years before death at 85 ; II, 6, double, quiet glaucoma 

 at 66, operated upon, died at 71 ; his wife (II, 14) died at 63 ; 3 of his 



siblings died in infancy, 2 others (II, 5 and 9) died as adults, all the 

 others living and reported to see well ; III, 1 to 7 issue of II, 6 and ] 4, 

 aged, at record, from 53 to 36, and all except III, 1 examined by author ; 

 III, 3 and 5 got glaucoma simplex at 48 and 40 respectively, and III, 2 

 had, at 52, signs of the incipient disease. In IV all are reported to 

 see well, the eldest of IV, 1 being 27, and of IV, 3, 29. 



Fig. 30 (Lawford, Case 8 : Nettleship, The Ophthalmoscope, September 

 and October, 1906). I, 1 affected at about 71 ; II, 1 at 45 ; III, 1 at 23. 



Fig. 31 (Lawford, Case 3) : I, 1 blind at 60, almost certainly from glau- 

 coma, died at 68 ; II, 1 attacked at 58 ; II, two years younger, attacked 

 at 47 ; II, 3, 6 other living siblings who see well ; II, 4, 4 who died. 



Fig. 32 (Lawford, Case 14) : I, 2 glaucoma at 47 ; of his 2 children by 

 first wife, II, 2 had glaucoma at 26, and of the two by third wife, II, 4 



