BOWMAN LECTURE. CLTX 



III, 5, set. 13 years, is just like III, 1 in his sight ; has been very short- 

 sighted and blind at night since early childhood ; now has about 10 D. of 

 myopia, with moderate crescents, but no other fundus changes ; read J. 

 3 and 4 fluently both with and without her glasses. Like her brother, 

 III, 1, she has always to be led home from evening church. The other 

 two have no defect. There is a history of " blindness " in a half-cousin, 

 biit no particulars were to be had. 



APPENDIX VI. 



LEBER'S DISEASE. 



(a) Abstracts of Published Cases in Chronological Order beginning with 

 r. Graefe's case, 1858, to which are added some hitherto unpublished 

 Cases communicated by friends or taken from my own note-books. 



The references down to 1899 are taken chiefly from Habershon's paper 

 in T.O.8., viii (1888), and Hormuth's Dissertation published in 1900 

 (title given on p. cxxxvii). The particulars of each case are also in 

 many instances taken from Hormuth's tables. When, however, his 

 abstract of a case seemed unsatisfactory reference was made to the 

 original ; but such reference has seldom led to any correction of 

 Hormuth's rendering. All cases consulted in the original are marked 

 with a star (*). 



1858. Case 70. v. Graefe, A. P.O., iv, 2, p. 256. 



Male, onset at twenty years of age ; failure progressed three months, 

 both eyes ; recovered to reading small print in four weeks ; no ophthalmo- 

 scopic note. His brother, onset set. 20 years, J. 20, no improvement ; 

 fundus normal three years later. Third brother, also attacked in same 

 way at nineteen. Parents normal. 



1862.* Case 71. Sedgwick, Med. Times and Gaz., i, p. 309. 



Usually quoted as Leber's disease, but the coincident family paralysis 



f 



and absence of ophthalmoscopic examination exclude precise diagnosis. 

 I, 1 blind from " amaurosis " at about 55. II, 1 amaurotic both eyes at 

 56 ; 2, living, Bet. 63 years, good eyes ; 3, died paralysed but good vision, 



