CLX[\r BOWMAN LECTURE. 



at 39, seen at 44; II, 2 affected at 12, seen at 33 ; II, 4 affected at 25, 

 died at 28 of diabetes ; II, 5 and 6, brothers, affected at 20. No con- 

 sanguinity. No record of any sisters in II. (Numerals omitted from 

 Figure, in error.} 



1882.* Case 96. Ibid. Family III. 



I, 1 affected at 20; I, 2, age at onset not stated; I, 3 normal. Of her 

 four children the youngest, II, 4, affected at 11 and seen soon after ; 

 eldest, II, 1, set. 24 years, and the two daughters, normal. I, 4 an 

 affected female cousin of I, 3. No consanguinity. 



1883. Case 97. De Keersmaecker, Recueil d'Ophtal., 1883, p. 193. 



Four brothers affected at 20, 40, 32, and 37 ; order of birth not recorded. 

 Also a male nephew at 19 ; presumably his mother was sister to the four 

 affected brothers, but this not stated. 



1885.* Case 98. Story, Ophthalmic Review, iv, p. 33. 



In a sibship of 8, 4 brothers and 4 sisters, the eldest brother affected 

 before 23, and died of epilepsy at 23 ; second brother affected at 21, died 

 of phthisis, and was alcoholic ; third brother affected as a young man, 

 and died in an asylum ; fourth brother affected at 30, was 45 at date 

 of record, and had had attacks of insanity. Of the sisters, the third, 

 affected at 40, was seen in the early stage at about same date as the 

 fourth brother ; her two older sisters (places in sibship not recorded) 

 very excitable ; youngest sister and eighth born normal. 



1885.* Case 99. Holz, "Drei Fiille von genuiner Atrophia nervor. 



opticor. simplex progressiva bei (resell wistern/'Jnawgr. Dissert., Greifswald. 



Notwithstanding the title the cases read like typical examples of 



I 2. 3 



Leber's disease. Parents (I, 1 and 2) and grandparents normal; II, 1, 

 set. 28 years, normal ; II, 2 affected at 22, seen at 23 (avithor's Case 3) ; 

 II, 3 affected at 18, and seen at same age and until 20 (author's Case 1) ; 

 II, 4, aet. 18 years, normal ; II, 5, affected at 15, seen nearly a year later 

 (author's Case 2). No improvement of II, 3 in two years. 



1887.* Case 100. Habershon, T.O.S., viii, p. 190. Author's Case 1. 



Two brothers ; one failed at 22 rapidly, seen at 31, had not improved; 

 My. 1'5 D., V. J. 19 ; married at 19, and had two children before eyes 

 failed, who are living and well. Other brother, five years younger, failed 



