BOWMAN LECTURE. CLXXXIII 



III, 5 failed at 19, and was seen three months later (author's Case 1) ; 



IV, 1, 2 and 3 all normal, and 110 miscarriages or early deaths ; IV, 4, 

 a seven months child, paralysis of lower limbs. 



1899.* Case 176. Ibid. Author's Cases 3 and 4. 



I, 1 died of phthisis at 35 ; I, 2 died blind and paralysed at 50, no 

 details of the blindness ; II, 1 progressive failure of V. at 48 and 

 optic atrophy found, at 50 sudden hemiplegia ; II, 3 died from heart 

 disease, blind, at 58, no details of the blindness ; either she or another 

 sister (II, 2) had a son (III, 6) who went " blind " at 30, no details ; III, 

 1 affected at 31, seen at 33, no recovery (author's Case 4), has 2 children 

 set. 8 and 7 years (IV, 1 and 2), and no miscarriages; III, 2 affected 

 during military service and recovered ; III, 3 affected at 27, seen soon 

 after (author's Case 3), has one child who died young; III, 4, five who 

 died young ; III, 5, two stillborn. 



1866.* Case 177. Hutchinson, R.L.O.H., v, p. 349. 



I, 1 and 2 first cousins, but kind of cousinship not noted ; II, 1 died at 

 4 months ; II, 2 said to have never seen, at 4 could only see large objects 

 and O.Ds. very atrophied (author's Case 2) ; III, 3 thought to have 

 seen well till 6 months old; at 1 years sees large objects, O.Ds. very 

 white. Both children intelligent and good tempered. Syphilis not 

 mentioned. No other history of blindness in family. This case has 

 sometimes been quoted as perhaps being an instance of Leber's con- 

 genital retinal atrophy without pigmentation. 



1907.* Case 178. Lawson (Arnold), T.O.S., xxvii, p. 169. 



I, 1 affected at 14, if not earlier ; L. much worse than E,., typical 

 scotoma in each ; now 31 (1907). II, 1 now 10 with typical scotoma in 

 each, affected since early infancy. II, 2 age not stated, sees quite well. 

 At date of record there had been no more births. 



1903.* Case 179. E. N., T.O.8., xxiii, p. 108. 



Male affected in 28th year, perfect recovery in a year or year and a 



half. His brother, ten years younger, attacked at 25 ; final result not 

 known. Two males, first cousins, had the disease at set. 28 and 35 years 

 respectively; the latter is said to have recovered perfectly, the former 

 did not. These two pairs of brothers were sons of two sisters. 



1894. Case 180. Konig (Hormuth, p. 94). 



Man, set. 22 years, no recovery in one year. A brother of his mother 

 (maternal uncle) and a cousin also on mother' side were blind of optic 



