BOWMAN LECTUEE. 



CLXXXV 



Case 1816.* Higgens, Lancet, 1881, ii, p. 869. 



Optic atrophy without other changes coming on in II, 4 at about 14 } 

 and reducing V. to finger-counting in a few months ; in II, 5 at 11, and 

 in II, 8 at 10. The disease set in in all three during about the first half 

 of 1881. Mother showed evident signs of syphilis shortly before birth of 



6 7 a 9 10 



II, 4 ; she also had four or five miscarriages (not marked on the diagram, 

 Fig. 181b) between II, 4 and 5 ; also II, 3 died at 14 months and II, 7 at 

 1 day old. II, 1, 2, 9, and 10 reported healthy. [If syphilis were the 

 cause of the optic atrophy in these three siblings, why did the disease set 

 in at approximately the same date (1881) in all of them? Was there 

 some additional cause, such as lead poisoning or influenza ? E.N.] 



Case 181c.* Suckling, Lancet, 1887, ii, p. 1271. 



I, 1 became blind at 50. II, 1 went completely blind from double optic 

 atrophy which came on gradually when he was 50 ; his sister, II, 2, was 

 blind, and a female cousin (II, 3) on his mother's side is also quite blind 

 (sex of I, 2 not given). No history of syphilis or disease of nervous 

 system, and no signs of locomotor ataxy. 



Wo information 



Fig. 181 D. 



Fig. I8ld. Unpublished. Case C3mmuiiicated by Mr. Ja.meson Evans 

 (Birmingham). 



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