BOWMAN LECTURE. CLXXXVII 



Condition of the Children of Affected Females. 



All the sons of an affected mother were affected in Cases 111, 138, and 

 146. 



Some of the sons of an affected mother escaped in Cases 108, 142, 50, 

 and 52. 



Proportion of affected to normal in the total surviving issue of an 

 affected mother and normal father, shown in 32 sibships of the following 

 9 pedigrees : 93, 49, 108, 116, 140, 50, 52, 51, 176. 



Proportion of affected to normal in the total surviving issue of normal 

 father, and mother normal but carrying the disease, shown in 38 sibships 

 of the following 19 pedigrees : 92, 102, 105, 45, 115, 46, 120, 130, 144, 47, 



148, 154, 48, 155, 168, 171, 174, 167. 



Effect of Early Deaths upon the Proportion of the Survivors who suffer, in 

 Childships originally consisting of Seven Children or more. 



In the following 10 cases there were 12 sibships of 7 or more, with few, if 

 any, early deaths, and one third of the individuals suffered from the disease. 



Total births, 102, of whom 33 males and 3 females got the disease (36 

 in all) : 110, 117, 130, 138, 142, 143, 47, 147, 158, 174. 



In the following 16 cases, containing 18 sibships of 7 or more, a number 

 of the children died early, and one half of the survivors suffered from the 

 disease : 92, 93, 45, 115, 119, 120, 121, 140, 141, 144, 148, 154, 51, 162, 176, 

 167. 



These 18 childships produced 195 children, of whom 96 died in infancy; 

 of the 99 survivors 39 males and 7 females got the disease (46 in all). 



Longevity of those Affected. 



The following cases contain affected persons who lived to be 50 or 

 more. Cases in which the disease set in after 40 in males are excluded. 

 All cases in females who lived to 50 are counted, at whatever age the 

 disease set in, as it has been supposed that the disease is especially likely 

 to occur during the climacteric in women : 90, 103, 49, 111, 45, 116, 120, 

 140, 142, 50, 52, 154, 51, 161, 166, 168, 172, 176. 



Early and Late Age of Onset. 



(i) Cases in which the disease occurred early in life, i. e. from earliest 

 childhood up to 13 years old: 92, 96, 95, 110, 116, 119, 141, 145, 50, 52, 



149, 151, 153, 156, 171, 177, 178, 146; also two atypical cases, 181, 181&. 

 (ii) Cases in which the disease set in late, i. e. from 30 years old up- 

 wards. 



A. Pedigrees showing examples of late onset in males : 



(1) In the following only males were affected: 89, 90, 103, 107, 45, 46, 

 120, 136, 143, 47, 147, 168, 175. 



(2) The following contained cases in both males and females : 93, 49, 

 111, 112, 141. 



B. Pedigrees showing late onset in females : 80, 49, 95, 98, 106, 108, 

 110, 111, 113, 140, 141, 153, 51, 162, 176 ; also atypical cases, 181a, 181c. 



