BOWMAN LECTURE. 



CXCVII 



III, 1, set. 24 years, eyes began to fail at about 16, but with interval of 

 three years between E. and L. ; now almost universal dense opacity ; 

 III, 2 began at 9, now 22, and as bad as III, 1 ; III, 4 disease began at 7 

 and has steadily got worse, and now, at 15, is nearly as bad as III, 2, and 

 has much severe acne on face* ; III, 5 began at about 11, seen at 12 ; 

 chief part of opacity showed much resemblance to "transverse cal- 

 careous film," and, as is common in that condition, showed numerous 

 small, clear holes. No consanguinity. 



Case 68a. A new case has been given to me this year by Mr. Herbert 

 Fisher, but as there has not yet been an opportunity for examining all 

 the available members of the family I withhold it ; at least two sisters are 

 affected, and probably two or three of their siblings. 



Fig. 69. Folker, T.O.S., xxix, p. 42 (1909). 



I, 1 now 92, history of first failure when about 50 ; about ten years later 



operated for cataract in both eyes ; wife living, has had 13 or 14 children, 

 7 still living, and no miscarriages. II, 3, now 50, sight "always" been 

 defective; 11 children, 8 living, 3 died under 2 years; II, 5, &t. 46 years, 

 sight " always " been defective ; has 9 children. Ill, 1, set. 30 years, sight 

 defective as long as she can remember, and apparently getting steadily 

 worse after each confinement ; has had 6 children in 8 years, one dying in 

 infancy, 5 living ; III, 2, set. 28 years, sight defective all his life, now 

 V. T 6 ; III, 4, set. 21 years, sight defective as long as she can remember, 

 now V. T <y, married, 1 child, set. 10 weeks ; III, 5, set. 18 years, no definite 

 history of commencement, but is getting worse, V. T \ ; III, 9, set. 21 

 years, has never noticed any defect of sight, and has now in R., in L., 

 but central area of each cornea shows 20 to 30 small scattered spots ; 

 III, 13, set. 12 years, no symptoms, and V. f with each eye, but has a few 

 small dots of corneal opacity like his brother. 



A general review of the disease illustrated by these pedigrees leaves 

 one in no doubt that it is often, if not always, progressive, that in an 

 early stage sight may be so little affected that nothing short of careful 



* Severe scar-leaving acne was observed by Marcus Gunn in one of his 

 cases : T.O.S., xix, p. 97. 



