34 THE BRADSHAW LECTURE 



have been always carried on by an abnormal ; but 

 the numbers of normal and abnormal, which should 

 be about equal, according to Mendel's law, when 

 an abnormal unites with a normal, shows a great 

 excess of normals above the Mendelian anticipa- 

 tion. 



MULTIPLE ABNORMALITIES. 



The frequent association of different abnormal- 

 ities, apparently quite unconnected, in the same 

 individual, is another point deserving close atten- 

 tion and careful study. It would seem that the 

 developmental process having once started in an 

 abnormal direction may fail in its complex details 

 at many points. Mr. Jackson Clarke published 

 a case of clubbed hand due to absence of the 

 radius associated with macrostoma in the first 

 volume of the ' Reports of the Society for the 

 Study of Disease in Children.' In the same 

 volume the late Dr. George Carpenter published 

 an account of two sisters, each of whom had a 

 keel-shaped skull, congenital heart disease, ventral 

 ruptures, webbed fingers, and six toes on each 

 foot, and was also mentally weak. The mother 

 was strong and healthy, and showed no deformity ; 

 but a cousin, the child of a maternal uncle, had 

 deformed hands. In the second volume Dr. 



