THE BRADSHAW LECTURE 35 



Hutchison and Dr. Sutherland published the 

 cases of two unrelated boys presenting exactly 

 the same deformities in association, viz. : (1) 

 Congenital heart disease, (2) a rudimentary hare- 

 lip, (3) six digits on each hand, (4) shortening 

 of the long bones of the extremities, and (5) 

 defective development of the gums. Many other 

 similar cases of multiple deformities might easily 

 be added; but I have mentioned sufficient, I 

 hope, to stimulate research into the origin of this 

 failure of control of the developmental process in 

 so many directions. 



GRADUAL INCREASE OF DEFORMITIES IN SUCCEEDING 

 GENERATIONS. 



The last point to which I desire to draw 

 particular attention is the origin of deformities 

 from small, easily overlooked, beginnings. I feel 

 sure a search for these will add much to our 

 knowledge, and it may be possible, by recognising 

 the forerunners, to prevent the development of 

 the graver deformities. Among minor deformities 

 the crooked little finger, which can easily be 

 shown to be tenaciously hereditary, has been 

 treated almost with scorn by Mendelians. Pro- 

 fessor Bateson writes : 



