THE BRADSHAW LECTURE 39 



the crooked little fingers and I throw on the screen 

 a sketch showing the gradual increase of this 

 defect in three generations. It is highly probable 

 that Nature throws out warning signals of danger 

 in the early stages of many hereditary deformities 

 which maybe discovered if a careful search be made 

 for minor defects among the immediate ancestors. 



Relation of the Absence of, or a Defective, Lateral 

 Incisor Tooth to Hare-lip and Cleft Palate in 

 Later Generation. 



I have only worked this out in the relation 

 of the lateral incisor tooth to hare-lip and cleft 

 palate, but I refer to it in order to stimulate 

 younger observers to turn their attention to this 

 important study, and I have one further observa- 

 tion as yet unpublished. My attention was first 

 drawn to it by observing that a gentleman who, 

 as a boy, was noticed to have an absence of the 

 left lateral incisor tooth, had an only daughter 

 who presented precisely the same defect on the 

 same side. As this only child has never married 

 there was no chance of proving the relation to 

 hare-lip and cleft palate in that family. It proved, 

 however, that the defect could be transmitted, 

 and that the transmission might be through the 

 opposite sex. Next, an infant was brought 

 among my out-patients suffering from hare-lip on 



